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Allergies Blog

By Daniel More, MD, About.com Guide to Allergies

Possible Link Between Singulair and Suicide

Friday March 28, 2008
The U.S. Food and Drug Administration (FDA) reported on Thursday, March 27 that they are investigating a possible link between Singulair and behavioral changes and suicidality. This investigation is apparently the result of recent reports of people attempting suicide who were taking Singulair at the time. While there were no reports of suicidality or behavioral changes involving 11,000 patients taking Singulair during the manufacturers' safety studies, there have been reports of these symptoms in people taking the medication since it has been marketed. The FDA states that this investigation will take approximately 9 months, after which the results will be reported to the public.

Singulair is an allergy and asthma medication that blocks leukotrienes, a chemical released from mast cells and other immune cells, that is involved in causing inflammation of the respiratory tract. Because Singulair could be controlling a person's asthma, it is important to speak with your doctor before stopping the medication if you have concerns about possible behavioral changes. It is also important to realize that just because a few people taking Singulair attempted suicide does not mean that the medication caused the behavioral changes. If you are taking Singulair and have concerns about this possible link, check with your doctor.

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