This is a very common problem -- when adhesives are in contact with the skin for prolonged periods of time (hours to days), a skin rash can occur in up to 50% of people. Usually, the skin rash is mild, appears red and bumpy, and is quite itchy. Once the adhesive is removed, the rash will usually go away within a number of days without treatment. In the case of transdermal patches for the delivery of medicine, the adhesive patch may be removed after a specified period of time and a new patch placed on a different area of the body. When the rash is allergic contact dermatitis (such as with poison oak, ivy or sumac), the body "remembers" where the rash had been before, and the rash may re-appear in the original area when the body is exposed again.
Diagnosis of Adhesive AllergyThe diagnosis of adhesive allergy is made by the use of patch testing. Patch testing can confirm what is already suspected based on a person's symptoms, but also identify the particular chemical that is causing the contact dermatitis. Patch testing also may reveal a problem other than an adhesive allergy – such as an allergy to latex, thiuram, or even to the drug itself. Latex allergy can be caused by IgE antibodies against the latex protein itself or contact dermatitis to thiuram, an accelerator used in the process of latex manufacturing. There have also been numerous reports of rashes caused by the active medication in transdermal patches, including nicotine. Therefore, the only way to know what exactly is causing the rash -– be it the adhesive, latex or medication -- is to have patch testing performed.
Treatment of Adhesive AllergyThe simplest treatment for adhesive allergy is to avoid exposure to the chemical causing the problem. In the cause of irritant-based contact dermatitis from a medicated transdermal patch, changing the location of the patch from week to week may be all that is needed. However, if the rash is severe, or extremely itchy, discontinuation of the medicated patch may be necessary. The rash itself is best treated with a topical corticosteroid – either with an over-the-counter product such as hydrocortisone 1% cream or with a stronger version available by prescription only.
Read more about common causes of contact dermatitis.
Ale I, Lachapelle JM, Maibach. Skin Tolerability Associated with Transdermal Drug Delivery Systems: An Overview. Adv Ther. 2009;26(10)920-35.
Stricker T, Sennhauser FH. Allergic Contact Dermatitis Due to Transdermal Contraception Patch. J Peds. 2006;148(6):845.
Kanerva L, Alanko K. Allergic Contact Dermatitis from 2-Hydroxyethyl Methacrylate in an Adhesive on an Electrosurgical Earthing Plate. Eur J Derm. 1998;8(7):521-4.
DISCLAIMER: The information contained in this site is for educational purposes only, and should not be used as a substitute for personal care by a licensed physician. Please see your physician for diagnosis and treatment of any concerning symptoms or medical condition.