Allergies Food Allergies Causes & Risk Factors What Is Watermelon Allergy? How Oral Allergy Syndrome Explains the Symptoms By Daniel More, MD Updated on August 15, 2023 Medically reviewed by Corinne Savides Happel, MD Print Pitipat Usanakornkul / EyeEm / Getty Images Table of Contents View All Table of Contents Symptoms Risk Factors Diagnosis When to See a Healthcare Provider Foods to Avoid Watermelon allergy symptoms are usually different from those caused by a typical food allergy. An allergic reaction to watermelon includes symptoms of oral allergy syndrome (OAS), also known as pollen food allergy syndrome (PFAS). OAS symptoms are caused by allergens found in both pollen and raw fruit, vegetables, and some nuts. If you are allergic to a specific type of pollen, for example, you may be allergic to foods that contain a comparable allergen. This is called cross-reactivity. This article explains watermelon allergy symptoms, diagnosis, and treatment. It also covers risk factors for developing a watermelon allergy and which foods to avoid if you develop OAS. Symptoms of Watermelon Allergy Unlike food allergies, which can cause systemic (body-wide) symptoms, watermelon allergy caused by OAS usually only produces localized itching and swelling. Symptoms of OAS include: Itchy mouthScratchy throatLips, mouth, tongue, throat swelling People with OAS usually only experience a reaction when eating raw fruits or vegetables because cooking alters the proteins involved. These symptoms typically begin immediately after putting the watermelon in your mouth and go away soon after swallowing it. Anaphylaxis While rare with OAS, anaphylaxis, a severe, life-threatening allergic reaction, can occur with any allergy. If you experience any of the following symptoms of anaphylaxis, seek medical attention right away: Hives Swelling Wheezing Unconsciousness Chest tightness Difficulty breathing Hoarseness Trouble swallowing Vomiting Diarrhea Stomach cramps Flushing A feeling of impending doom Is Watermelon Good for Weight Loss? Risk Factors for Watermelon Allergy A ragweed allergy is associated with OAS reactions to watermelons. Though anyone can develop OAS, the condition is less common in young children. What Causes Watermelon Allergy? Certain foods correlate with particular environmental allergens. For example, if you are allergic to various types of melons, you may also experience allergic rhinitis (nasal allergies) caused by ragweed pollen. OAS symptoms are your body reacting to the proteins in the fruit that resemble those in pollen. This cross-reactivity confuses the immune system, resulting in OAS symptoms. Other common correlations include the following. Birch pollen: apple, almond, carrot, celery, cherry, hazelnut, kiwi, peach, pear, plum Grass pollen: celery, melons, oranges, peaches, tomato Ragweed pollen: banana, cucumber, melons, sunflower seeds, zucchini While the above associations are possible, they do not exist for everyone. For example, a person with birch pollen allergy may have OAS when eating apples but not react to any other foods associated with birch pollen. Similarly, a person may have a ragweed pollen allergy and only notice oral symptoms with melons. Watermelon Allergy in Children and Babies A 2015 study published in the International Dental Journal evaluated the prevalence of OAS in children. In 120 kids with seasonal allergic rhinitis, OAS symptoms were most pronounced in those with a birch allergy. In addition, OAS was more common in teens than older children and more prevalent in those with allergic rhinitis and asthma, and allergic rhinitis and eczema. In some cases, a person may not experience an allergic reaction to watermelon for years, but suddenly develop OAS later in life. How is Watermelon Allergy Diagnosed? A careful history can usually provide enough clues to a healthcare provider that watermelon is the culprit. However, some diagnostic tools can help them confirm it. Allergy testing may include: A skin test, in which an allergist (an allergy specialist) scratches your skin with an allergen and watches for a reaction A blood test, in which a lab technician evaluates your blood for IgE antibodies. Levels of these antibodies rise in people with allergies. An oral food challenge, in which you consume foods you might be allergic to and document any reaction In oral allergy syndrome to watermelon (pollen food allergy syndrome), watermelon allergy tests can be negative. When to See a Healthcare Provider Because the symptoms are mild and fade quickly, treatment is not usually necessary in people with a watermelon allergy. Still, if you experience symptoms of OAS, it's a good idea to make an appointment with an allergist or your primary healthcare provider for a diagnosis. However, if you experience symptoms of anaphylaxis, like difficulty breathing, swelling, or hives, seek emergency medical care immediately. To avoid another severe reaction, a healthcare provider will likely prescribe an EpiPen. An EpiPen is an injectable device that contains a synthetic form of the hormone epinephrine. Injecting the hormone can stop the reaction and give you time to seek emergency medical care. First Aid for Anaphylaxis If you or anyone else experiences symptoms of an anaphylactic reaction, use an EpiPen if the person experiencing symptoms has one prescribed. Then call 911 or head to an emergency room immediately. Other measures to take with or without an EpiPen include: Having the person lie down and elevating the legs. This helps maintain blood flow to the heart during anaphylactic shock. Having the person sit upright if they are having trouble breathing or if they are vomiting. Monitoring the person's pulse and breathing and administering CPR if necessary. Foods to Avoid If you have a watermelon allergy, avoid consuming watermelon. In addition to whole watermelon, keep an eye out for watermelon in salads, drinks, and smoothies. People with OAS often have reactions to more than one food. If you have a ragweed allergy, you may also react when you eat these foods: BananaCantelopeChamomileCucumberEchinaceaHoneydewSunflower seedsZucchini If you notice a reaction to these or any other foods, add them to your list of foods to avoid. Summary In some people, eating watermelon can trigger oral allergy syndrome. If you have an allergy to a specific type of pollen, a specific protein in watermelon can trigger the same type of reaction. This is called cross-reactivity. Symptoms are immediate and localized and include itching and tingling in the mouth and throat. They usually resolve quickly once you've swallowed the fruit. Rarely, anaphylaxis can occur. Avoiding watermelon prevents a reaction. For severe reactions, using an EpiPen and getting emergency medical attention is key. 6 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. American College of Allergy, Asthma & Immunology. Oral Allergy Syndrome. American College of Allergy, Asthma & Immunology. Pollen food allergy syndrome. UpToDate. Patient education: Oral allergy syndrome (Beyond the basics). American Academy of Allergy, Asthma & Immunology. Anaphylaxis. Ivković-Jureković I. Oral allergy syndrome in children. Int Dent J. 2015;65(3):164-168. doi:10.1111/idj.12164 American Academy of Allergy, Asthma, and Immunology. Oral allergy syndrome (OAS). By Daniel More, MD Daniel More, MD, is a board-certified allergist and clinical immunologist. He is an assistant clinical professor at the University of California, San Francisco School of Medicine and formerly practiced at Central Coast Allergy and Asthma in Salinas, California. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit